Blar i forfatter "Nikolaisen, Trygg Einar"

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    • The hypotonic environmental changes affect liposomal formulations for nose-to-brain targeted drug delivery 

      Wu, Iren Yeeling; Nikolaisen, Trygg Einar; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-16)
      Systemic administration of drugs is ineffective in the treatment of central nervous system disorders because of the blood-brain barrier. Nasal administration has been suggested as an alternative administration route as drugs absorbed in the olfactory epithelium bypass the blood-brain barrier and reach the brain within minutes. However, the nasal mucosa properties (e.g., tonicity, pH) are not constant ...

    • Influence of environmental tonicity changes on lipophilic drug release from liposomes 

      Nikolaisen, Trygg Einar (Mastergradsoppgave; Master thesis, 2018-05-15)
      Introduction: Liposomes as drug delivery systems has been widely studied as a way to solubilize poorly soluble drugs, reduce side effects of chemotherapeutics and increase circulation time in vivo. Since the first descriptions of liposomes over 60 years ago, they have shown tendencies to shrink and swell when the external environment of the liposomes is altered. This phenomenon has been studied in ...